I am Doug, welcome to my profile! My highest weight at one time was 312 pounds, after a long duration on the bipolar medication Depakote. I was switched from Depakote to more "weight neutral" medications in 2007, but I still find that they contribute to my weight issues (everyone responds differently to each and every psych medication, unfortunately). It seems like if I do not get enough exercise I do not lose any weight, even keeping calories in check. My motivation for exercise comes and goes with my mood fluctuations, and health issues. I have severe seasonal allergies and get a sinus infection about once a year, and recently have been diagnosed with back issues too. Despite challenges I have now lost 100 pounds and counting! We CAN do this.